Anticonvulsant drugs based on the neurochemistry of seizures.
نویسندگان
چکیده
منابع مشابه
In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures
Background: Resistance to antiepileptic drugs as well as intolerability in 20-30% of the patients raises demand for developing new drugs with improved efficacy and safety. Acceptable anticonvulsant activity, good tolerability, and inexpensiveness of docosahexaenoic acid (DHA), make it as a good candidate for designing and development of the new anticonvulsant medications. Methods: Ten DHA-based...
متن کاملInhibitory and Dose-dependent effect of intracerebroventricular docosahexaenoic acid on clonic seizures induced by pentylenetetrazole in mice
Introduction: Epilepsy is one of the most common neurologic disorders. Pharmacoresistance and adverse effects of current antiepileptic drugs (AEDs) necessitate development of new drugs and strategies for treatment of epilepsy. Omega 3-Polyunsaturated fatty acids (ω3-PUFAs) are safe nutritional supplements that recently considered for treatment of epilepsy. Anticonvulsant effect of docosahexa...
متن کاملRetinol and ?-Carotene inhibit PTZ-induced kindling in mice
Vitamin A and its derivatives have recently reported to be implicated in synaptic plasticity. The possible effect of vitamin A and its precursor, ?-carotene, on seizure acquisition was tested in PTZ kindling model of epilepsy. Vitamin A and ?-carotene were tested for their ability to 1) suppress seizures (clonic and tonic) and lethality induced by PTZ in PTZ-kindled mice (anticonvulsant effect)...
متن کاملAnticonvulsant Effect of Alcea aucheri on Pentylenetetrazole and Maximal Electroshock Seizures in Mice
Introduction: This study was designed to investigate the possible anticonvulsant effect of acute administration of an aqueous extract of flowers of Alcea aucheri (EFA) in a seizure model. Methods: Seizures were induced in male adult Swiss mice by administration of pentylenetetrazol (PTZ) or Maximal Electroshock (MES). Mice were randomly subjected to receive saline, EFA (8.75-175 mg.kg-1), or d...
متن کاملRetinol and ?-Carotene inhibit PTZ-induced kindling in mice
Vitamin A and its derivatives have recently reported to be implicated in synaptic plasticity. The possible effect of vitamin A and its precursor, ?-carotene, on seizure acquisition was tested in PTZ kindling model of epilepsy. Vitamin A and ?-carotene were tested for their ability to 1) suppress seizures (clonic and tonic) and lethality induced by PTZ in PTZ-kindled mice (anticonvulsant effect)...
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عنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 6 شماره
صفحات -
تاریخ انتشار 1962